Gymnema Sylvestre Leaf Powder - Organic (1 lb)

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The history of this plant goes back 2000 years in Indian culture and medicine. Gymnema sylvestre is a woody, climbing perennial which grows primarily in the tropical forests of central and southern India as well as parts of Africa. The name of this powerful plant in Urdu means “the destroyer of sugar”. The leaves, which are primarily responsible for its medicinal properties, are traditionally chewed and interfere with one’s ability to taste sweetness. Gymnemic acid is what science believes to be the primary components of its beneficial properties.

While this herb has been used for over 2000 years as a traditional part of ayurvedic medicine, it was 1920 when preliminary studies began to find evidence of this herb’s medicinal action and how it may support the body’s ability to maintain healthy blood sugar levels. Much of the research, over the years, has concluded that this herb affects two areas of physiology. The taste buds in the oral cavity which first detect the flavor of sugar and the absorptive surface of the small intestine. The structure of both the taste buds and the tissue that absorbs the sugar into the intestines are very similar in nature. Most of these studies also strongly suggest that the herb’s ability to support healthy blood sugar levels is due to the presence of the active ingredient gymnemic acid (its structure is made up of triterpenoid, glucuronic acid and several fatty acids). It is believed that these effects are due to the arrangement of molecules in this active ingredient which are similar to those of a glucose molecule. The research shows that these molecules bind to receptor sites on the taste buds for a period of 1-2 hours preventing them from being activated by any sugar present in food. These glucose like molecules may act in the exact same way in the intestines: filling the receptor locations in a case of mistaken identity. While Gymnema has been known to take away the sweet and bitter tastes; it has been shown to have no effect on other types of taste like pungent and salty.

There have been many human studies that have shown the potential for this powerful herb and its supportive qualities. One study took 22 people with type 2 insulin dependency who were taking oral insulin along with 400 mgs of Gymnema Sylvestre extract daily. The results were a significant reduction in blood sugar, hemoglobin A1c and plasma protein levels. This shows that this herb may possibly support the body’s ability to release its own insulin. It was also concluded that Gymnema may work by possibly supporting the regeneration of b-cells. B cells are a type of white blood cell known as lymphocytes. This is a part of your adaptive immune system involved in forming specific responses to certain antigens. Another study of 27 people with type one insulin dependency were given 400 mgs daily of gymnema in extract form and after 10-12 months the results were quite positive. There was a reduction in fasting blood sugar levels, hemoglobin A1c and plasma protein levels which in turn reduced the requirement for insulin. Finally, a study in 1986 suggested that consistent use of this herb may possibly support healthy liver and pancreatic function. This shows Gymnema Sylvestre may have great potential for a variety of issues. Please keep in mind that when we use studies as evidence for showing the effectiveness of this herb, the studies are done with specific standardized or full spectrum extracts.

Some possible traditional uses of Raw Organic Gymnema Sylvestre Leaf Powder May include:

● May support healthy blood sugar levels
● May support healthy lipid levels
● May support liver health
● 2000 year history in Ayurvedic medicine
● May support pancreatic health
● May support sugar regulation in taste buds and intestines

Constituents of Gymnema Sylvestre Leaf include:

● Gymnemic Acids I-IV, Tartaric Acic, Gurmarin, triterpenoid, glucuronic acid, Stigmasterol, Gymnemasaponin I-VII, Gymnemasin A-D

For additional constituent information, visit:
https://phytochem.nal.usda.gov/phytochem/plants/show/995

Suggested Use: Take 1 teaspoons with meals or snacks. It will block any sweet taste so some people prefer to take it after eating or drinking something that contains sugar or put the powder in a capsule.

Other Preparations:

Infusion: Use the ratio of 1 teaspoon of product for every 8 ounces of distilled water. Bring water to a boil and then take off stove. Put tea in pot or a mug fill with water and cover for 15 minutes. This method is specific for whole leaf herbs and teas.

Tincture: This method can take 15 to 30 days. You will need 3 items including a mason jar with cover, the herb/herbs of your choice, liquid for extracting. The extracting liquid can be alcohol, alcohol/water combo, vinegar or vegetable glycerin. Take the product and fill the jar ¾ full, add the liquid of your choice and close the jar. Then shake the jar so everything is well mixed. Give the jar a good 5 minute shake several times a day. After 15 to 30 days strain and bottle in glass tincture jars.

Mixing Suggestions: To increase flavor and nutritional profile combine with our Organic Cinnamon powder.

Botanical Name: Gymnema Sylvestre.

Other names: Gemnema Melicida, Gimnema, Gur-Mar, Gurmar, Gurmarbooti, Gymnema montanum, Gymnema sylvestre, Gymnéma, Gymnéma Sylvestre, Madhunashini, Merasingi, Meshashringi, Miracle Plant, Periploca sylvestris, Shardunika, Vishani.

Parts Used: Gymnema Sylvestre Leaf.

Ingredients: Raw Gymnema Sylvestre Leaf.

Origin: Grown and dried in India. Packaged with care in Florida, USA.

Certifications: USDA Certified Organic.

Z Natural Foods strives to offer the highest quality organically grown, raw, vegan, gluten free, non-GMO products available and exclusively uses low temperature drying techniques to preserve all the vital enzymes and nutrients. Our Raw Gymnema Sylvestre Leaf Powder is USDA Certified Organic and passes our strict quality assurance which includes testing for botanical identity, heavy metals, chemicals and microbiological contaminants. ZNaturalFoods.com offers Raw Organic Gymnema Sylvestre Leaf Powder packaged in airtight stand-up, resealable foil pouches for optimum freshness. Once opened, just push the air out of the pouch before resealing it in order to preserve maximum potency. Keep your Organic Raw Gymnema Sylvestre Leaf Powder in a cool, dark, dry place.

References:

1. Ananthan R, Baskar C, NarmathaBai V, et al. Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes. Pharmacol Res 2003;48(6):551-556.

2. Cicero AF, Derosa G, Gaddi A. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetol 2004;41(3):91-98.

3. Gholap S, Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie 2003;58(6):413-415.

4. Khare AK, Tondon RN, Tewari JP. Hypoglycaemic activity of an indigenous drug (Gymnema sylvestre, "Gurmar") in normal and diabetic persons. Indian J Physiol Pharm 1983;27:257-258.

5. Kothe A, Uppal R. Antidiabetic effects of Gymnema sylvestre in NIDDM - a short study. Indian J Homeopath Med 1997;32(1-2):61-62, 66.

6. Meiselman HL, Halpern BP. Effects of Gymnema sylvestre on complex tastes elicited by amino acids and sucrose. Physiol Behav 1970;5(12):1379-1384.

7. Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie 2003;58(1):5-12.

8. Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6(3):171-180.

9. Satdive RK, Abhilash P, Fulzele DP. Antimicrobial activity of Gymnema sylvestre leaf extract. Fitoterapia 2003;74(7-8):699-701.

10. Shanmugasundaram ERB, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharm 1990;30(3):281-294.

11. Shapiro K, Gong WC. Natural products used for diabetes. J Am Pharm Assoc (Wash) 2002 Mar-Apr;42(2):217-26.

12. Simons CT, O'Mahony M, Carstens E. Taste suppression following lingual capsaicin pre-treatment in humans. Chem Senses. 2002 May;27(4):353-65.

13. Xie JT, Wang A, Mehendale S, et al. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacol Res 2003;47(4):323-329.

14. Ye W, Liu X, Zhang Q, et al. Antisweet saponins from Gymnema sylvestre. J Nat Prod 2001 Feb;64(2):232-5.

15. Yeh GY, Eisenberg DM, Kaptchuk TJ, et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26(4):1277-1294.

16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170951/

17. http://www.ncbi.nlm.nih.gov/pubmed/2259216

18. http://www.ncbi.nlm.nih.gov/pubmed?term=Baskaran%20K%20et%20al.20effect%20of%20a%20leaf%20extract%20from%20gymnema%20sylvestre%20in%20non-insulin-dependent%20diabetes%20mellitus%20patients

19. Brala PM, Hagen RL. Effects of sweetness perception and caloric value of a preload on short term intake. Physiol Behav. 1983 Jan;30(1):1-9.

20. Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J Agric Food Chem. 2012 Mar 14;60(10):2517-24. doi: 10.1021/jf205086b.

21. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct;30(3):295-300.

22. Al-Romaiyan A, Liu B, Docherty R, Huang GC, Amiel S, Persaud SJ, Jones PM. Investigation of intracellular signalling cascades mediating stimulatory effect of a Gymnema sylvestre extract on insulin secretion from isolated mouse and human islets of Langerhans. Diabetes Obes Metab. 2012 Jul 6;9999(9999). doi: 10.1111/j.1463-1326.2012.01660.x.

23. Daisy P, Eliza J, Mohamed Farook KA. A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J Ethnopharmacol. 2009 Nov 12;126(2):339-44. doi: 10.1016/j.jep.2009.08.018. Epub 2009 Aug 22.

24. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct;30(3):295-300.

25. http://www.globalhealingcenter.com/natural-health/weight-loss-benefits-of-gymnema/

26. http://www.livestrong.com/article/357938-gymnema-herb-benefits/

27. http://www.webmd.com/vitamins-supplements/ingredientmono-841-gymnema.aspx?activeingredientid=841&activeingredientname=gymnema

28. http://www.nuturna.com/gymnema-sylvestre

29. http://intelegen.com/nutrients/gymnema_sylvestre_for_diabetes.htm

30. K.G. Gharpurey, Indian Medical Gazette 1926; 61: 155 (Abstr).

31. K.S. Mhaskar, J.G. Caius, Indian Medical Research Memoirs 1930; 16: 2-75.

32. K.R. Shanmugasundaram, C. Panneerselvam, P. Samudram, et al, Pharmacological Research Communications 1981; 13: 475-486.

33. E.R.B. Shanmugasundaram, M. Venkatasubramanyam, M. Vijendran, et al, Ancient Science of Life 1988; 8: 183-194.

34. E.R.B. Shanmugasundaram, K.L. Gopinath, K. Rhada Shanmugasundaram, et al, Journal of Ethnopharmacology 1990; 30: 265-279.

35. K. Baskaran, B. Kizar Ahamath, K. Radha Shanmugasundaram, et al, Journal of Ethnopharmacology 1990; 30: 295-300.

36. E.R.B. Shanmugasundaram, G. Rajeswari, K. Baskaran, et al, Journal of Ethnopharmacology 1990; 30: 281-294.

37. Ananthan R, Baskar C, NarmathaBai V, et al. Antidiabetic effect of Gymnema montanum leaves: effect on lipid peroxidation induced oxidative stress in experimental diabetes. Pharmacol Res 2003;48(6):551-556.

38. Cicero AF, Derosa G, Gaddi A. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetol 2004;41(3):91-98.

39. Gholap S, Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: involvement of thyroid hormones. Pharmazie 2003;58(6):413-415.

40. Khare AK, Tondon RN, Tewari JP. Hypoglycaemic activity of an indigenous drug (Gymnema sylvestre, "Gurmar") in normal and diabetic persons. Indian J Physiol Pharm 1983;27:257-258.

41. Kothe A, Uppal R. Antidiabetic effects of Gymnema sylvestre in NIDDM - a short study. Indian J Homeopath Med 1997;32(1-2):61-62, 66.

42. Meiselman HL, Halpern BP. Effects of Gymnema sylvestre on complex tastes elicited by amino acids and sucrose. Physiol Behav 1970;5(12):1379-1384.

43. Porchezhian E, Dobriyal RM. An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie 2003;58(1):5-12.

44. Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6(3):171-180.

45. Satdive RK, Abhilash P, Fulzele DP. Antimicrobial activity of Gymnema sylvestre leaf extract. Fitoterapia 2003;74(7-8):699-701.

46. Shanmugasundaram ERB, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharm 1990;30(3):281-294.

47. Shapiro K, Gong WC. Natural products used for diabetes. J Am Pharm Assoc (Wash) 2002 Mar-Apr;42(2):217-26.

48. Simons CT, O'Mahony M, Carstens E. Taste suppression following lingual capsaicin pre-treatment in humans. Chem Senses. 2002 May;27(4):353-65.

49. Xie JT, Wang A, Mehendale S, et al. Anti-diabetic effects of Gymnema yunnanense extract. Pharmacol Res 2003;47(4):323-329.

50. Ye W, Liu X, Zhang Q, et al. Antisweet saponins from Gymnema sylvestre. J Nat Prod 2001 Feb;64(2):232-5.

51. Yeh GY, Eisenberg DM, Kaptchuk TJ, et al. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26(4):1277-1294.

52. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170951/

53. http://www.ncbi.nlm.nih.gov/pubmed/2259216

54. http://www.ncbi.nlm.nih.gov/pubmed?term=Baskaran%20K%20et%20al.20effect%20of%20a%20leaf%20extract%20from%20gymnema%20sylvestre%20in%20non-insulin-dependent%20diabetes%20mellitus%20patients

55. Brala PM, Hagen RL. Effects of sweetness perception and caloric value of a preload on short term intake. Physiol Behav. 1983 Jan;30(1):1-9.

56. Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J Agric Food Chem. 2012 Mar 14;60(10):2517-24. doi: 10.1021/jf205086b.

57. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct;30(3):295-300.

58. Al-Romaiyan A, Liu B, Docherty R, Huang GC, Amiel S, Persaud SJ, Jones PM. Investigation of intracellular signalling cascades mediating stimulatory effect of a Gymnema sylvestre extract on insulin secretion from isolated mouse and human islets of Langerhans. Diabetes Obes Metab. 2012 Jul 6;9999(9999). doi: 10.1111/j.1463-1326.2012.01660.x.

59. Daisy P, Eliza J, Mohamed Farook KA. A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J Ethnopharmacol. 2009 Nov 12;126(2):339-44. doi: 10.1016/j.jep.2009.08.018. Epub 2009 Aug 22.

60. Bishayee A, Chatterjee M. Hypolipidemic and antiatherosclerotic effects of oral Gymnema sylvestre R. Br. leaf extract in albino rats fed on a high fat diet. Phytother Res 1994;8:118–20.

61. Diabetes: herbal remedies that may help control blood sugar. In: The Complete Natural Health Reference Guide. Discovery Health (http://www.discoveryhealth.com).

62. Duke JA. The Green Pharmacy. Emmaus, PA: Rodale Press, Inc., 1997.

63. Reitchenberg-Ullman J. Can you just say no to sugar? Healthworld Online (http://www.healthworldonline.com), January 17, 2001.

64. Squier TBB, Peden LD. Herbal Folk Medicine. New York: Henry Holt and Company, 1997.

65. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990 Oct;30(3):295-300.


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