Anti-aging

In the realm of gerontology, aging is scientifically delineated as a time-dependent decrement in physiological functions crucial for survival and reproduction, segmented into five distinct stages: self-sufficiency, interdependence, dependence, crisis management, and end of life (Bishop et al., 2010, Nature Reviews Molecular Cell Biology; FDA Guidelines for Nutritional and Dietary Supplements). Research identifies seven interconnected processes that contribute to aging, including stress adaptation via the hypothalamic-pituitary-adrenal (HPA) axis, epigenetic modifications impacting gene expression, inflammation, macromolecular damage, proteostasis related to cellular health regulation, and stem cell regeneration (López-Otín et al., 2013, Cell; NIH Research). This intricate framework offers a comprehensive biomedical understanding of aging, emphasizing the need for evidence-based interventions to support healthy aging (WHO Recommendations; USDA Guidelines). The multifaceted nature of aging processes underscores the importance of integrated, evidence-based research for developing targeted nutritional and dietary supplement strategies (NIH Clinical Trials).